Search results for "biomedical application"
showing 10 items of 20 documents
Histone Deacetylase Inhibitors from Marine Invertebrates
2020
Simple Summary Histone deacetylases (HDACs) are enzymes that control gene expression and are involved in the onset of serious human pathologies, including cancer; hence, their inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of molecules showing active pharmacological properties and an extensive spectrum of biomedical applications. This review is focused on the description of the molecular, biochemical, and, where available, physiological aspects of marine invertebrate-derived compounds that possess HDACi properties, taking into consideration their possible utilization as treatment agents against differe…
PREPARATION OF MACROMOLECULAR MATERIALS FOR BIOMEDICAL APPLICATIONS
2012
Galvanic deposition and characterization of brushite/hydroxyapatite coatings on 316L stainless steel
2016
In this work, brushite and brushite/hydroxyapatite (BS, CaHPO4·H2O; HA, Ca10(PO4)6(OH)2) coatings were deposited on 316L stainless steel (316LSS) from a solution containing Ca(NO3)2·4H2O and NH4H2PO4 by a displacement reaction based on a galvanic contact, where zinc acts as sacrificial anode. Driving force for the cementation reaction arises from the difference in the electrochemical standard potentials of two different metallic materials (316LSS and Zn) immersed in an electrolyte, so forming a galvanic contact leading to the deposition of BS/HA on nobler metal. We found that temperature and deposition time affect coating features (morphology, structure, and composition). Deposits were char…
Optimisation non-lisse pour l'estimation de composants immunitaires cellulaires dans un environnement tumoral
2021
In this PhD proposal we will investigate new regularization methods of inverse problems that provide an absolute quantification of immune cell subpopulations. The mathematical aspect of this PhD proposal is two-fold. The first goal is to enhance the underlying linear model through a more refined construction of the expression matrix. The second goal is, given this linear model, to derive the best possible estimator. These two issues can be treated in a decoupled way, which is the standard for existing methods such as Cibersort, or as a coupled optimization problem (which is known as blind deconvolution in signal processing).
Functionalization of Graphene with Molecules and/or Nanoparticles for Advanced Applications
2019
Graphene is considered the material of the third millennium, due to its extraordinary electronic and mechanical properties, and due to the possibility to modulate its conductivity, flexibility, elasticity, transparency, and biocompatibility by bottom-up approach. The possibility to gather the proper- ties of graphene and graphene oxide with those of functional moieties or nanoparticles is herein reviewed. The synthetic approaches proposed, either covalent or noncovalent, are aimed to tune appropriately graphene’s properties for the realization of materials for advanced uses, such as bio- medical applications, sensors, catalysis, and energy devices. In particular, methods based on covalent l…
Halloysite nanotubes for efficient loading, stabilization and controlled release of insulin
2018
Hypothesis: Oral insulin administration is not actually effective due to insulin rapid degradation, inactivation and digestion by proteolytic enzymes which results in low bioavailability. Moreover insulin is poorly permeable and lack of lipophilicity. These limits can be overcome by the loading of protein in some nanostructured carrier such as halloysite nanotubes (HNTs). Experiments: Herein we propose an easy strategy to obtain HNT hybrid materials for the delivery of insulin. We report a detailed description on the thermal behavior and stability of insulin loaded and released from the HNTs hybrid by the combination of several techniques. Findings: Release experiments of insulin from the H…
Hyaluronan-Based Graft Copolymers Bearing Aggregation-Induced Emission Flurogens
2017
In order to develop a technology platform based on two natural compounds from biorenewable resources, a short series of hyaluronan (HA) copolymers grafted with propargylated ferulic acid (HA-FA-Pg) were designed and synthesized to show different grafting degree values and their optical properties were characterized in comparison with reference compounds containing the same ferulate fluorophore. Interestingly, these studies revealed that the ferulate fluorophore was quite sensitive to the restriction of intramolecular motion and its introduction into the rigid HA backbone, as in HA-FA-Pg graft copolymers, led to higher photoluminescence quantum yield values than those obtained with the isola…
Effect of interfacial area on heterogeneous free radical grafting of vinyl monomers in supercritical carbon dioxide: Grafting of acrylic acid on poly…
2014
The role of the polymer interfacial area on free radical grafting of acrylic acid (AA) onto poly(vinylidenefluoride) (PVDF) was studied at 65°C using supercritical carbon dioxide (scCO2) as a solvent and swelling agent, benzoylperoxide (BPO) as chemical initiator and PVDF nanoparticles as polymer matrix. Under adopted conditions PVDF particles do not melt neither dissolve in the reaction medium and FTIR analyses performed on carefully washed nanoparticles confirmed the achievement of high grafting levels. The mass fraction of grafted AA increased with the grafting time and the BPO concentration while it decreased when the density of the fluid phase was enhanced. Collected results suggest th…
Poly(lactic acid)/carvacrol-based materials: preparation, physicochemical properties, and antimicrobial activity
2020
The current demand for new antimicrobial systems has stimulated research for the development of poly(lactic acid)/carvacrol (PLA/CAR)-based materials able to hinder the growth and spread of microorganisms. The eco-friendly characteristics of PLA and cytocompatibility make it very promising in the perspective of green chemistry applications as material for food and biomedical employments. The broad-spectrum biological and pharmacological properties of CAR, including antimicrobial activity, make it an interesting bioactive molecule that can be easily compounded with PLA by adopting the same techniques as those commonly used for PLA manufacturing. This review critically discusses the most comm…